publications

Sebastian Mueller, MD, PhD

Professor of Medicine,

Department of Medicine,

Salem Medical Center

University of Heidelberg

[ Home ] [ Research ] [ Former Affiliations ] [ Publications ] [ Conferences ] [ Equipment ] [ Links ]

Home

Original Papers (Medline)

Additional Book Chapters and Reviews

Patents

Original Papers and PUBMED

Please ask for reprints by email

50. The effect of low oxygen with and without steady-state hydrogen peroxide on cytokine gene and protein expression of monocyte-derived macrophages - biomed 2011. Owegi H, Li H, Bouwens M, Egot-Lemaire S, Mueller S, Geib RW, Waite GN. Biomed Sci Instrum. 2011;47:58-63. Related citations

49. Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis. Patsenker E, Stoll M, Millonig G, Agaimy A, Wissniowski T, Schneider V, Mueller S, Brenneisen R, Seitz HK, Ocker M, Stickel F. Mol Med. 2011 Aug 19. doi: 10.2119/molmed.2011.00149. [Epub ahead of print] PMID:21863215 Free Article Related citations

48. Investigation of tumor hypoxia using a two-enzyme system for in vitro generation of oxygen deficiency.

Askoxylakis V, Millonig G, Wirkner U, Schwager C, Rana S, Altmann A, Haberkorn U, Debus J, Mueller S, Huber PE.

Radiat Oncol. 2011 Apr 10;6:35. Free PMC Article PMID:21477371[PubMed - in process] Free full text Related citations

47. Transient micro-elastography: A novel non-invasive approach to measure liver stiffness in mice.

Bastard C, Bosisio MR, Chabert M, Kalopissis AD, Mahrouf-Yorgov M, Gilgenkrantz H, Mueller S, Sandrin L.

World J Gastroenterol. 2011 Feb 28;17(8):968-75. Free PMC Article Related citations

46. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.

Stickel F, Buch S, Lau K, Zu Schwabedissen HM, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Mueller S, Seitz HK, Soyka M, Lerch M, Lammert F, Sarrazin C, Kubitz R, Häussinger D, Hellerbrand C, Bröring D, Schreiber S, Kiefer F, Spanagel R, Mann K, Datz C, Krawczak M, Wodarz N, Völzke H, Hampe J.

Hepatology. 2011 Jan;53(1):86-95. doi: 10.1002/hep.24017. Epub 2010 Dec 7.PMID: 21254164 [PubMed - in process]Related citations

45. Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions.

Millonig G, Wang Y, Homann N, Bernhardt F, Qin H, Mueller S, Bartsch H, Seitz HK.

Int J Cancer. 2011 Feb 1;128(3):533-40.PMID: 20715111 [PubMed - indexed for MEDLINE]Related citations

44. Increased iron in HCV infection: Collateral damage or antiviral defense?

Mueller S.

J Hepatol. 2010 Aug 22. [Epub ahead of print] No abstract available. PMID: 20850193 [PubMed - as supplied by publisher] Related citations

43. Heme Oxygenase-1 and Iron in Liver Inflammation: a Complex Alliance.

Immenschuh S, Baumgart-Vogt E, Mueller S.

Curr Drug Targets. 2010 Aug 13. [Epub ahead of print]PMID: 20704547 [PubMed - as supplied by publisher] Related citations

42. Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract.

Vijayan V, Mueller S, Baumgart-Vogt E, Immenschuh S.

World J Gastroenterol. 2010 Jul 7;16(25):3112-9.PMID: 20593496 [PubMed - in process]Free PMC Article Free textRelated citations

41. Liver stiffness: a novel parameter for the diagnosis of liver disease

Sebastian Mueller, Laurent Sandrin

Hepatic Medicine: Evidence and Research Published Date May 2010 , Volume 2010:2 Pages 49 - 67

40. Gastrointestinal stromal tumor in a patient with undiagnosed neurofibromatosis type I: an uncommon cause of extrahepatic cholestasis.

Millonig G, Giesel FL, Reimann FM, Topalidis T, Seitz HK, Mueller S.

Z Gastroenterol. 2010 Apr;48(4):479-81. Epub 2009 Dec 2.PMID: 20352594 [PubMed - in process] Related citations

39. Hyperferritinaemia-cataract syndrome: worldwide mutations and phenotype of an increasingly diagnosed genetic disorder.

Millonig G, Muckenthaler MU, Mueller S.

Hum Genomics. 2010 Apr;4(4):250-62.PMID: 20511138 [PubMed - in process] Related citations

38. Increased liver stiffness in alcoholic liver disease: Differentiating fibrosis from steatohepatitis.

Mueller S, Millonig G, Sarovska L, Friedrich S, Reimann FM, Pritsch M, Eisele S, Stickel F, Longerich T, Schirmacher P, Seitz HK.

World J Gastroenterol. 2010 Feb 28;16(8):966-72.PMID: 20180235 [PubMed - in process] Related articles Free article

37. Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study.

Millonig G, Praun S, Netzer M, Baumgartner C, Dornauer A, Mueller S, Villinger J, Vogel W.

Biomarkers. 2010 Feb 15. [Epub ahead of print]PMID: 20151876 [PubMed - as supplied by publisher] Related articles

36. The GOX/CAT system: A novel enzymatic method to independently control hydrogen peroxide and hypoxia in cell culture.

Mueller S, Millonig G, Waite GN.

Adv Med Sci. 2009 Nov 27:1-15. [Epub ahead of print]PMID: 20022860 [PubMed - as supplied by publisher] Related articles

35. Liver stiffness is directly influenced by central venous pressure.

Millonig G, Friedrich S, Adolf S, Fonouni H, Golriz M, Mehrabi A, Stiefel P, Pöschl G, Büchler MW, Seitz HK, Mueller S.

J Hepatol. 2009 Dec 4. [Epub ahead of print]PMID: 20022130 [PubMed - as supplied by publisher] Related articles

34. [Hereditary hyperferritinemia cataract syndrome--the first family in Germany]

Millonig G, Holzer MP, Tolle G, Auffarth GU, Muckenthaler MU, Seitz HK, Mueller S.

Z Gastroenterol. 2009 Dec;47(12):1211. German. PMID: 19994473 [PubMed - in process] Related articles

33. Current Experimental Perspectives on the Clinical Progression of Alcoholic Liver Disease.

Breitkopf K, Nagy LE, Beier JI, Mueller S, Weng H, Dooley S.

Alcohol Clin Exp Res. 2009 Jul 23. [Epub ahead of print]

PMID: 19645734 [PubMed - as supplied by publisher] Related Articles

32. Alcoholic liver disease and hepatitis C: a frequently underestimated combination.

Mueller S, Millonig G, Seitz HK.

World J Gastroenterol. 2009 Jul 28;15(28):3462-71.

PMID: 19630099 [PubMed - in process] Related Articles Free article in PMC | at journal site

31. Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease.

Wang Y, Millonig G, Nair J, Patsenker E, Stickel F, Mueller S, Bartsch H, Seitz HK.

Hepatology. 2009 Aug;50(2):453-461. PMID: 19489076 [PubMed - as supplied by publisher] Related Articles

30. The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis.

Weng HL, Liu Y, Chen JL, Huang T, Xu LJ, Godoy P, Hu JH, Zhou C, Stickel F, Marx A, Bohle RM, Zimmer V, Lammert F, Mueller S, Gigou M, Samuel D, Mertens PR, Singer MV, Seitz HK, Dooley S.

Hepatology. 2009 Jul;50(1):230-43. PMID: 19441105 [PubMed - indexed for MEDLINE] Related Articles

29. In vitro-targeted gene identification in patients with hepatitis C using a genome-wide microarray technology.

Hagist S, Sültmann H, Millonig G, Hebling U, Kieslich D, Kuner R, Balaguer S, Seitz HK, Poustka A, Mueller S.

Hepatology. 2009 Feb;49(2):378-86.

PMID: 19177570 [PubMed - indexed for MEDLINE] Related Articles

28. Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1C polymorphism.

Homann N, König IR, Marks M, Benesova M, Stickel F, Millonig G, Mueller S, Seitz HK.

Alcohol Clin Exp Res. 2009 Mar;33(3):551-6. Epub 2008 Dec 19.

PMID: 19120062 [PubMed - indexed for MEDLINE] Related Articles

27. Hypoxia-inducible factor 1a under rapid enzymatic hypoxia: Cells sense decrements of oxygen but not hypoxia per se.

Millonig G, Hegedüsch S, Becker L, Seitz HK, Schuppan D, Mueller S.

Free Radic Biol Med. 2009 Jan 15;46(2):182-191. Epub 2008 Nov 1.

PMID: 19007879 [PubMed - as supplied by publisher] Related Articles

26. Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis.

Millonig G, Reimann FM, Friedrich S, Fonouni H, Mehrabi A, Büchler MW, Seitz HK, Mueller S.

Hepatology. 2008 Nov;48(5):1718-23. PMID: 18836992 [PubMed - indexed for MEDLINE] Related Articles

25. Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network.

Andriopoulos B, Hegedüsch S, Mangin J, Riedel HD, Hebling U, Wang J, Pantopoulos K, Mueller S.

J Biol Chem. 2007 Jul 13;282(28):20301-8. Epub 2007 May 21. PMID: 17517884 [PubMed - indexed for MEDLINE] Related Articles Free article at journal site

24. Compartment-dependent management of H(2)O(2) by peroxisomes.

Fritz R, Bol J, Hebling U, Angermüller S, Völkl A, Fahimi HD, Mueller S.

Free Radic Biol Med. 2007 Apr 1;42(7):1119-29. Epub 2007 Jan 12. PMID: 17349938 [PubMed - indexed for MEDLINE] Related Articles

23. Liver-homing of purified glucose oxidase: a novel in vivo model of physiological hepatic oxidative stress (H2O2).

Rost D, Welker A, Welker J, Millonig G, Berger I, Autschbach F, Schuppan D, Mueller S.

J Hepatol. 2007 Mar;46(3):482-91. Epub 2006 Nov 17. PMID: 17188390 [PubMed - indexed for MEDLINE] Related Articles

22. Iron, HCV, and liver cancer: hard metal setting the pace?

Mueller S, Afdhal NH , Schuppan D.

Gastroenterology. 2006 Jun;130(7):2229-34. No abstract available.PMID: 16762645 [PubMed - indexed for MEDLINE] Related Articles

21. Iron regulatory protein 1 as a sensor of reactive oxygen species.

Mueller S.

Biofactors. 2005;24(1-4):171-81. PMID: 16403978 [PubMed - indexed for MEDLINE] Related Articles

20. Cardioprotective effects of the novel selective endothelin-A receptor antagonist BSF 461314 in ischemia-reperfusion injury.

Hansen A, Bekeredjian R, Filusch A, Wolf D, Gross ML, Mueller S, Korosoglou G, Kuecherer HF.

J Am Soc Echocardiogr. 2005 Nov;18(11):1213-20. PMID: 16275532 [PubMed - indexed for MEDLINE] Related Articles

19. Gender-specific expression of liver organic anion transporters in rat.

Rost D, Kopplow K, Gehrke S, Mueller S, Friess H, Ittrich C, Mayer D, Stiehl A.

Eur J Clin Invest. 2005 Oct;35(10):635-43. PMID: 16178883 [PubMed - indexed for MEDLINE]

18. Extracellular H2O2 and not superoxide determines the compartment-specific activation of transferrin receptor by iron regulatory protein 1.

Sureda A, Hebling U, Pons A, Mueller S.

Free Radic Res. 2005 Aug;39(8):817-24. PMID: 16036361 [PubMed - indexed for MEDLINE]

17. Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography.

Hansen A, Kumar A, Wolf D, Frankenbergerova K, Filusch A, Gross ML, Mueller S, Katus H, Kuecherer H.

J Am Coll Cardiol. 2004 Aug 18;44(4):887-91. PMID: 15312876 [PubMed - indexed for MEDLINE]

16. Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1.

Mütze S, Hebling U, Stremmel W, Wang J, Arnhold J, Pantopoulos K, Mueller S.

J Biol Chem. 2003 Oct 17;278(42):40542-9. Epub 2003 Jul 29. Erratum in: J Biol Chem. 2003 Dec 5;278(49):49662. PMID: 12888561 [PubMed - indexed for MEDLINE]

15. Sensitive and real-time determination of H2O2 release from intact peroxisomes.

Mueller S, Weber A, Fritz R, Mütze S, Rost D, Walczak H, Völkl A, Stremmel W.

Biochem J. 2002 May 1;363(Pt 3):483-91. PMID: 11964148 [PubMed - indexed for MEDLINE]

14. Activation of iron regulatory protein-1 by oxidative stress.

Mueller S, Pantopoulos K.

Methods Enzymol. 2002;348:324-37. PMID: 11885287 [PubMed - indexed for MEDLINE]

13. [Therapy of alcoholic and non-alcoholic fatty liver]

Stremmel W, Blechacz B, Herrmann T, Rost D, Mueller S.

Internist (Berl). 2001 Dec;42(12):1641-2, 1645-50. Review. German. No abstract available. PMID: 11793603 [PubMed - indexed for MEDLINE]

12. IRP1 activation by extracellular oxidative stress in the perfused rat liver.

Mueller S, Pantopoulos K, Hübner CA, Stremmel W, Hentze MW.

J Biol Chem. 2001 Jun 22;276(25):23192-6. Epub 2001 Apr 10. PMID: 11297549 [PubMed - indexed for MEDLINE]

11. Extrapulmonary sarcoidosis primarily diagnosed in the liver.

Mueller S, Boehme MW, Hofmann WJ, Stremmel W.

Scand J Gastroenterol. 2000 Sep;35(9):1003-8. Review. PMID: 11063165 [PubMed - indexed for MEDLINE]

10. Sensitive and nonenzymatic measurement of hydrogen peroxide in biological systems.

Mueller S.

Free Radic Biol Med. 2000 Sep 1;29(5):410-5. PMID: 11020662 [PubMed - indexed for MEDLINE]

9. p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression.

Mueller S, Cadenas E, Schönthal AH.

Cancer Res. 2000 Jan 1;60(1):156-63. PMID: 10646868 [PubMed - indexed for MEDLINE]

8. Role of p53 in aziridinylbenzoquinone-induced p21waf1 expression.

Wu RC, Hohenstein A, Park JM, Qiu X, Mueller S, Cadenas E, Schönthal AH.

Oncogene. 1998 Jul 23;17(3):357-65. PMID: 9690517 [PubMed - indexed for MEDLINE]

7. Direct evidence for catalase as the predominant H2O2 -removing enzyme in human erythrocytes.

Mueller S, Riedel HD, Stremmel W.

Blood. 1997 Dec 15;90(12):4973-8. PMID: 9389716 [PubMed - indexed for MEDLINE]

6. Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.

Pantopoulos K, Mueller S, Atzberger A, Ansorge W, Stremmel W, Hentze MW.

J Biol Chem. 1997 Apr 11;272(15):9802-8. PMID: 9092514 [PubMed - indexed for MEDLINE]

5. Determination of catalase activity at physiological hydrogen peroxide concentrations.

Mueller S, Riedel HD, Stremmel W.

Anal Biochem. 1997 Feb 1;245(1):55-60. PMID: 9025968 [PubMed - indexed for MEDLINE]

4. Fast and sensitive chemiluminescence determination of H2O2 concentration in stimulated human neutrophils.

Mueller S, Arnhold J.

J Biolumin Chemilumin. 1995 Jul-Aug;10(4):229-37. PMID: 8533604 [PubMed - indexed for MEDLINE]

3. Mechanisms of inhibition of chemiluminescence in the oxidation of luminol by sodium hypochlorite.

Arnhold J, Mueller S, Arnold K, Sonntag K.

J Biolumin Chemilumin. 1993 Nov-Dec;8(6):307-13. PMID: 8285109 [PubMed - indexed for MEDLINE]

2. Chemiluminescence intensities and spectra of luminol oxidation by sodium hypochlorite in the presence of hydrogen peroxide.

Arnhold J, Mueller S, Arnold K, Grimm E.

J Biolumin Chemilumin. 1991 Jul-Sep;6(3):189-92. PMID: 1746319 [PubMed - indexed for MEDLINE]

1. On the action of hypochlorite on human serum albumin.

Arnhold J, Hammerschmidt S, Wagner M, Mueller S, Arnold K, Grimm E.

Biomed Biochim Acta. 1990;49(10):991-7. PMID: 1964376 [PubMed - indexed for MEDLINE]

Book Chapters and Reviews

16. Waite, G.N., Millonig, G., Seitz, H.K., Mueller, S. A novel enzymatic method to study hypoxia and oxidative stress (hydrogen peroxide) on cultured cells. In: Pantopoulos, K., Schipper, H. (eds) Free Radical Biomedicine, 2010, (accepted for publication)

15. Waite, G.N., Millonig, G., Seitz, H.K, Mueller, S. Ultrasensitive chemiluminescence detection of hydrogen peroxide In: Pantopoulos, K., Schipper, H. (eds) Free Radical Biomedicine, 2010, (accepted for publication)

14. Seitz HK, Mueller S. Alkohol, Tabak und Karzinogenese. In: Alkohol, Tabak und Folgeerkrankungen. Singer, M.V. et al (eds.) 2010 (accepted for publication)

13. Seitz HK, Mueller S. Alkohol und Sucht: Einfluss von Alkohol auf die Krebsentstehung, Pharma Fokus Onkologie, 49-53. 2010

12. Seitz, H.K., Millonig, G., Mueller, S. Alcohol and cancer. In: Drug Abuse and Addiction in Medical Illness: causes, consequences and treatment, Verster JC (ed.), Humana Press Totowa NJ (USA) 2010 (in press)

11. Millonig, G., Mueller, S., Seitz, H.K. Alkohol und Ernährung. In: Ernährungsmedizin. Biesalksi, Bischoff, Puchstein (eds) Thieme Verlag Stuttgart New York, 2010 (in press)

10. Seitz HK, Mueller S. Alcoholic liver disease. In: Clinical Hepatology: Principles and Practice of Hepatobiliary Diseases. Dancygier H (ed.) Springer Publ. Heidelberg, Dordrecht , London , New York pp 1111-52. 2009

9. Seitz, H.K., Mueller S. Alcohol consumption. Encyclopedia of Cancer, 2nd Edition (ed. M. Schwab), Springer Heidelberg , New York , pp 107-109. 2008.

8. Fritz, R., Völkl, A., Stremmel, W., and Mueller, S. H₂O₂-Release from Intact Peroxisomes: New Insights into Peroxisome-Derived Oxidative Stress. In: C. Pasquier (ed.), Proceedings of the 11th Biennal Meeting of the Society for Free Radical Research International, pp. 35-43. Bologna: Monduzzi Editore, 2002.

7. Mütze, S., Arnhold, J., Stremmel, W., and Mueller, S. Sensitive detection of hydrogen peroxide in biological systems: A non-enzymic approach. In: S. G. Pandalai (ed.), Recent Research Developments in Analytical Biochemistry, Vol. 2, pp. 165-184: Transworld Research Network, 2002.

6. Mueller, S. and Arnhold, J. Light emission by luminol and its application. In: S. Albrecht, T. Zimmermann, and H. Brandl (eds.), Chemiluminescence at the turn of the millenium - an indispensable tool in modern chemistry, biochemistry and medicine, pp. 23-28. Dresden : Schweda, 2001.

5. Mueller, S. Sensitive and nonenzymatic measurement of hydrogen peroxide in biological systems. In: W. A. Pryor (ed.), Bio-assays for oxidative stress status (BOSS), pp. 170-175. New York : Elsevier, 2001.

4. Schönthal, A. H., Mueller, S., and Cadenas, E. Redox regulation of p21, role of reactive oxygen and nitrogen species in cell cycle progression. In: C. K. Sen, H. Sies, and P. A. Baeurle (eds.), Antioxidant and redox regulation of genes, pp. 311-336. San Diego : Academic Press, 2000.

3. Mueller, S., Riedel, H. D., and Stremmel, W. Chemiluminescence determination of catalase at physiological H₂O₂ concentrations. In: J. W. Hastings, L. J. Kricka, and P. E. Stanley (eds.), Bioluminescence and chemiluminescence: molecular reporting with photons, pp. 462-465. Baffins Lane , Chichester , Sussex : John Wiley & Sons Ltd, 1997.

2. Mueller, S., Pantopoulos, K., Hentze, M. W., and Stremmel, W. A chemiluminescence approach to study the regulation of iron metabolism by oxidative stress. In: J. W. Hastings, L. J. Kricka, and P. E. Stanley (eds.), Bioluminescence and chemiluminescence: molecular reporting with photons, pp. 338-341. Baffins Lane , Chichester , Sussex : John Wiley & Sons Ltd, 1997.

1. Mueller, S. and Arnhold, J. Detection of hydrogen peroxide in stimulated neutrophils using luminol and hypochlorite. In: A. K. pp. 242-245. CCampbell, L. J. Kricka, and P. E. Stanley (eds.), Bioluminescence and chemiluminescence: Fundamentals and Applied Aspects,hichester , New York , Brisbane , Toronto , Singapore : John Wiley & Sons, 1994.

Monographs

2. Mueller, S. Habilitation: Hydrogen peroxide as potential intercellular signaling molecule as exemplified by hepatic iron regulation. University of Heidelberg , 2003.

1. Mueller, S. Promotion: Chemiluminescence in the system luminol/hypochloric acid: a method to determine hydrogen peroxide in activated neutrophils. University of, 1994.

Patents

1. Mueller, S. and J. Arnhold (1993). “Verfahren zur Bestimmung von Wasserstoffperoxid.” Patent: angemeldet am 8. 4. 1993; P 4312097.