Department of Internal Medicine IV            

University of Heidelberg            

                      Sebastian Mueller Group            

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topics mueller                           


Present Studies

molecular control of iron homeostasis by oxidative stress
signaling function, metabolism and compartmentalization of hydrogen peroxide
peroxisomes as source of cellular oxidative stress: role in apoptosis, redox-regulation and liver disease
role of oxidative stress in NASH (non-alcoholic steatosis hepatitis)
generation of a tet-regulated liver-specific GOX mouse
decelopment of a human and murine "liver chip" to detect redox-specific gene expression patterns


Ultrasensitive detection of H2O2 in biological samples 


Former Studies

analysis of hydrogen peroxide in biological systems
enzymology of catalase
cell-cycle regulation and cell adhesion functions 
cell-cycle and chemotherapeutic agents
oxygen burst cascade of neutrophils