Sebastian Mueller, MD, PhD

Professor of Medicine,

CAR, University of Heidelberg 

VISCERA AG Bauchmedizin Bern 

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The Center for Alcohol Research (CAR) is located at the Otto Meyerhof Center of the University of Heidelberg. Major goals are to better understand disease-mechanisms of chronic alcohol consumption, namely alcoholic liver disease and cancer. The CAR team consists of physicians, scientists, technicians and study nurses. CAR is headed by Sebastian Mueller (Director).

                     S. Mueller (direction)

Actual translational research topics focus on 

• liver diseases

• alcoholic liver disease

• cancer (hepatocellular and colorectal cancer)

• non-invasive diagnosis of liver fibrosis

• fatty liver and steatohepatitis

• iron overload disorders

• liver stiffness and novel book published in 2020

• prospective long-term follow-up study in heavy drinkers on survival and other parameters (2007-2022, still in analysis)

Actual basic research topics are related to

• molecular mechanisms of oxidative stress 

• redox-regulation

• detection of reactive oxygen species

• novel models for oxidative stress and hypoxia

• inflammation and iron homeastasis 

• mechanisms of alcohol-mediated cancerogenesis

• biomechanics and extracellular matrix (fibrosis and cirrhosis)

• in vitro erythrophagocytosis

Center Team

Study doctors:

Ongoing clinical studies:

1. Non-invasive diagnosis of liver steatosis by CAP

2. Non-invasive diagnosis of liver cirrhosis

3. Non-invasive diagnosis of liver iron overload by susceptometry

4. Alcohol and cancer (breast, colon cancer etc.)

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Former team members:

Vanessa Rausch, PhD Group leader, Molecular biology vanessa.rausch@uni-heidelberg.de	Julia Mutzek  Study coordination Julia.Mutzek@stadtmission-hd.de	Antje Hagedorn-Dambuk Study coordinationHagedorn-Dambuk Antje Antje.Hagedorn-Dambuk@stadtmission-hd.de

Past AMG studies

1.  Hepatoprotective effects of Nalmefene, DELIVER  (PI: Mueller, S.)

2. CALVADOS study. Hepatoprotective alcohol detoxification with chlromethiazole (PI: Seitz, H.K., Ko-PI: Mueller, S.)