Sebastian Mueller, MD, PhD

Professor of Medicine,

CAR, University of Heidelberg 

VISCERA AG Bauchmedizin Bern 

Present Studies

Basic Research

• molecular control of iron homeostasis by oxidative stress
• molecular control of oxygen
• signaling function, metabolism and compartmentalization of hydrogen peroxide
• peroxisomes as source of cellular oxidative stress: role in apoptosis, redox-regulation and liver disease
• role of oxidative stress in NASH (non-alcoholic steatosis hepatitis)
• mechanisms of liver fibrosis
• alcohol-mediated cancerogenesis

Clinical Studies

• non-invasive diagnosis of fibrosis (liver, kidney)
• confounding factors of liver stiffness
• alcohol serum marker
• hepatic iron overload disorders
• diagnosis and treatment of alcoholic liver disease

Ultrasensitive detection of H2O2 in biological samples 

Former Studies

• analysis of hydrogen peroxide in biological systems
• enzymology of catalase
• cell-cycle regulation and cell adhesion functions 
• cell-cycle and chemotherapeutic agents
• oxygen burst cascade of neutrophils